The defense later stopped the Rams on fourth down. Those possessions mattered in a game in which Arizona repeatedly had to settle for kicks, including on its five trips into the red zone.
Brissett finished with 218 passing yards. Bam Knight rushed for 80 yards on 15 carries, although cramps limited him after halftime. Tyler Allgeier added 38 yards on 18 attempts.
Brooks sets up the final kick
Matthew Stafford brought Los Angeles back with a late touchdown drive. Puka Nacua's 42-yard reception helped move the Rams downfield before Stafford found Colby Parkinson for a 6-yard touchdown with 47 seconds remaining.
Punter Ethan Evans made the extra point for a 16-15 lead. He had taken over kicking duties after Blake Grupe injured his knee making a tackle on a kickoff. Grupe was subsequently ruled out.
Arizona answered immediately. Brissett hit Jalen Brooks for 21 yards, and a 15-yard unnecessary-roughness penalty against Josh Wallace extended the gain. Allgeier then gained five yards before Ryland finished the game.
FOX Sports' official video shows the winning kick: