Boyd allowed four runs and five hits over four innings, with four strikeouts and one walk. That left the Cubs chasing a pitcher who was denying them solid contact. Chicago had runners in scoring position in the second and third but failed to bring either home. Crow-Armstrong and Alex Bregman finished a combined 0-for-7 with six strikeouts.
The game widened in the fifth. Jackson Merrill singled home two runs after San Diego loaded the bases against Javier Assad; Ty France then scored on Carson Kelly's passed ball. Tatis added the final run in the seventh, scoring after a steal and Kelly's throwing error. The Padres finished with 13 hits.
Chicago's last chance came against Joe Musgrove in the ninth. Seiya Suzuki and Hoerner singled, and Dansby Swanson walked, but Musgrove struck out pinch-hitter Michael Conforto with the bases loaded to finish the shutout. Chicago struck out 11 times.
The Cubs now need consecutive wins to advance. The Chicago Tribune reported that Kevin Gausman's pregame bullpen went well enough for him to start Game 2 after concerns about his left shoulder. Chicago's lineup has a more immediate job: produce runs before San Diego can hand another lead to its rested late-inning relievers.