Washington also came up short on a fourth-down attempt at the San Francisco 17. Malik Mustapha tackled Jeremy McNichols for no gain on third-and-3 at the San Francisco 17, then defended Daniels' fourth-down throw toward Treylon Burks. Washington got the ball back after a punt and drove into scoring range again, but could not finish.
Purdy completed 21 of 29 passes for 264 yards and a touchdown. McCaffrey had 64 rushing yards and two scores, plus nine catches for 53 yards. Kittle caught five passes for 69 yards. Daniels finished 29 of 40 for 300 yards, two touchdowns and no interceptions; Washington converted three of 12 third downs.
The teams also lost leading receivers. Terry McLaurin was carted off with a knee injury in the first quarter after one catch for 27 yards. Mike Evans left late in the second with an Achilles injury after three catches for 94 yards. Both were ruled out, and Washington also lost defensive tackle Javon Kinlaw to a knee injury. Shanahan said after the game that Evans had aggravated the Achilles soreness he had been managing during the week and that he did not expect additional testing.
Washington fell to 1-4-1. San Francisco finished with 375 yards to the Commanders' 314.
Correction: The final sack is credited to Keion White and Romello Height. An earlier version named Ogbo Okoronkwo instead of White.