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Nick Bosa injury watch: what the 49ers have confirmed
San Francisco ruled Bosa out against Denver with knee and calf issues. His Seattle availability needs the new week’s report.
4 sources / Updated October 5, 2026
Nick Bosa did not play against Denver on October 4. San Francisco's official inactive announcement identifies knee and calf injuries and lists him among the players ruled out for the Week 4 game. That is the confirmed starting point for Ohio State fans following the former Buckeye before the 49ers' trip to Seattle. 49ers inactive announcement
The next game is scheduled for October 11 at 4:25 p.m. Eastern. Bosa's Week 4 designation does not establish whether he will be available for Week 5. Each week's report describes that week's preparations and game status, so a Seattle preview should wait for the Seattle report before calling him available or ruled out. ESPN schedule
The 49ers' injury table lists Bosa as a nonparticipant in each of the three practices for the Denver game. The team's legend defines nonparticipation separately from limited and full participation. Those practice labels report the amount of work completed; the game designation states the club's availability judgment for the matchup. 49ers injury report
For viewers, the distinction prevents an easy mistake. A name appearing on a roster is not evidence that the player will dress on Sunday. A change in practice participation can be relevant without settling the final decision. The official game-status report and inactive list provide the more direct answers.
If Bosa returns, his actual defensive participation will become the next question. The fact that a player is active does not alone establish how much he will play. Watch the rotations and then check the official participation record. Avoid assigning a full workload from a pregame clearance.
For now, the published evidence supports a narrower statement: San Francisco ruled him out against Denver with knee and calf issues. The next update belongs to Seattle week. Buckeyes fans planning their Sunday viewing should check the 49ers' new report and final inactives, with no return date assumed from the previous week's listing.